EFFECTS OF THE HYPERLIPIDIC DIET, CONTAINING SATURATED FAT, ON THE BONE QUALITY OF WISTAR MACHOS RATS IN THE ADULT LIFE
DOI:
https://doi.org/10.12957/demetra.2019.34223Keywords:
High fat diet. Rats. Bone. Dietary fats. Adult.Abstract
Objectives: To evaluate the influence of pork lard intake on the bone composition of male rats at 120 days of age. Methods: Male Wistar rats from from a laboratory of a federal University of Rio de Janeiro. The animals were kept in a room with temperature (25 to 27ºC), light / dark cycle (12-12h), receiving ad libitum water during 8 weeks. The groups, divided into: control, which received casein (GC, n = 12) and experimental fed pig lard (GH, n = 12) rations, were followed up to 120 days. The femur was adequately reserved for future analysis. Statistical analysis was performed using the GraphPadPrism program (version 5.00, 2007, San Diego, USA). Results: The results were expressed as mean ± standard error of the mean (SEM), considering the level of significance of P<0.05. The GH (6.938 ± 0.030 mm) had a greater (p<0.05) diaphysis width than the GC (4.430 ± 0.040 mm). In the biomechanical test, the maximum strength (GC = 102,200 ± 10,210N and GH = 126,100 ± 4,341N) and the elastic modulus (GC = 471415 ± 44457MPa and GH = 570013 ± 24575MPa) were higher in the hyperlipid group (p<0.05), respectively. The femoral bone composition was higher (p<0.05) GH BMD (0.15 ± 0.001g / cm²) than the CG (0.144 ± 0.002g / cm²). Discussion and Conclusions: The hyperlipid diet containing saturated fat influenced the bone structure, but did not reduced bone quality.
DOI: 10.12957/demetra.2019.34223
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