Impact of immunonutrient use on clinical out comes in critical patients: a systematic review of clinical trials
DOI:
https://doi.org/10.12957/demetra.2023.77540Keywords:
Imunomodulação. Estado crítico. Avaliação de Resultados em Cuidados de SaúdeAbstract
Objective: To describe the outcomes regarding the impact of immunonutrients on mortality rates, length of hospitalization, duration of Intensive Care Unit (ICU) stays, and the incidence of infections in adult and elderly critical patients. Method: An integrative literature review was conducted using the PubMed, LILACS, SciELO, Medline, and Google Scholar databases, using the descriptors: ("immunomodulation" OR "immunonutrients") AND ("fatty acids, Omega-3" OR "eicosapentaenoic Acid") AND ("glutamine") AND ("critical illness" OR "critical illnesses" OR "critically ill"), without language restrictions. The search encompassed studies that were published between 2012 and 2022. Results: Fifteen publications were identified in the conducted searches, of which eleven met all the established criteria at the outset of the study. Although some studies involving individuals supplemented with immunomodulatory formulas demonstrated improvements in ICU length of stay, a reduced incidence of sepsis and septic shock, and a lower infection rate, most of the evaluated studies did not reveal significant differences between the supplemented groups and the control groups or did not yield statistically significant outcomes. Conclusion: The management of care for critical patients necessitates a cautious and individualized approach, underpinned by scientific evidence. The analysis of clinical studies forming part of this research revealed an absence of statistically significant results pertaining to the practice of immunomodulation utilization in critical patients with respect to effects on mortality, ICU length of stay, total hospitalization, and the incidence of infections. Further studies are required to validate the genuine benefits of adopting this approach.
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Copyright (c) 2023 Yasmym Dannielle Souza, Jorvana Stanislav Brasil Moreira, Talita Ariane Amaro Lobato, Rafaela Lorena Viana Costa, Lilia Magno de Abreu Teixeira
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