OROPHARYNGEAL ADMINISTRATION OF MOTHER’S COLOSTRUM: A LITERATURE REVIEW
DOI:
https://doi.org/10.12957/demetra.2018.29813Keywords:
Human milk. Preterm newborn. Colostrum.Abstract
Introduction: Premature births are considered a public health problem. Estimates indicate that approximately 30% of preterm newborns present complications inherent to this condition due to an immature immune response, as well as the immaturity of their digestive tract, which cause important long-term sequelae, such as growth deficit, delay in neurodevelopment, impairment of vision and hearing, with irreparable damage to children's health. Colostrum therapy is an admittedly safe technique that uses maternal colostrum to provide preterm infants with early immunological protection. This article aims to answer the following question: what is the impact of colostrum therapy on the health of premature infants? Objective: To review the evidence on the benefits of colostrum therapy for preterm infants. Methodology: Narrative review of the literature. The search for the articles was done in the databases of Pubmed, Cochrane, Virtual Health Library, Medline EBSCO, Proquest, Embase and Banco de Teses da Capes, without language restriction or publication period. Gray literature included unpublished theses, dissertations and abstracts. The descriptors used in the search strategy were: human milk, premature and colostrum. In addition, the terms "colostrum therapy", "colostrum oropharyngeal administration" and "colostrum oral administration" were used. Results: The results of nine studies were included in this review, being eight controlled and one observational. Different endpoints were measured in the studies, with approaches related to nutrition and growth, clinical outcomes, assessment of oral mucosa colonization of the newborn, and evaluation of immune development mediators, such as serum immunoglobulin A and lactoferrin secreted in the urine. When comparing the groups that received the colostrum with the control groups, the findings are positive, such as a shorter time to reach the full enteral diet, a higher mean weight at 36 weeks of life, a protective effect for sepsis development, and better breastfeeding rates at hospital discharge than children who did not receive colostrum therapy. Conclusions: Although there is no strong evidence of the clinical impact of colostrum therapy, it does not pose a risk for children. More evidence is needed on the impact of colostrum therapy on the prevention of clinical outcomes of higher incidence in premature infants to support the widespread implantation of this practice in neonatal units.
DOI: 10.12957/demetra.2018.29813
Downloads
Downloads
Published
How to Cite
Issue
Section
License
STATEMENT OF AUTHORSHIP RESPONSIBILITY
Title of the manuscript:
________________________________________________________
1. Statement of responsability
I certify that I have participated in the work above specified and take public responsibility for its content.
I certify that the manuscript represents an original work and that none of the material in the manuscript has been previously published, is included in another manuscript, or is currently under consideration for publication elsewhere, whether in printed form or in electronic media, except that described in the attachment.
In case of acceptance of this text by Demetra: Alimentação, Nutrição & Saude, I declare to be in accordance with the policy of public access and copyright adopted by Demetra, which provides as follows: (a) the authors retain the copyright and grant to the Journal the right of first publication, the work being simultaneously licensed under the Creative Commons Attribution License, which allows the sharing of the work with acknowledgment of authorship and initial publication in this journal; (b) authors are authorized to enter additional contracts separately for non-exclusive distribution of the version of the work published in this journal (eg, publishing in institutional repository or book chapter), with acknowledgment of authorship and initial publication in this journal; and (c) authors are permitted and encouraged to post and distribute their work online (eg, in institutional repositories or on their personal page) at any point before or during the editorial process, as this may lead to productive changes, as well as increase the impact and citation of the published work.
2. Conflict of Interest Statement
I certify that there is no conflict of interest in connection with the submitted article.
Date, signature and full address of all authors.
