Sarcopenia and quality of life in hospitalized patients with hematologic neoplasms
DOI:
https://doi.org/10.12957/demetra.2025.89403Keywords:
Sarcopenia. Hematologic neoplasms. Quality of life. Nutritional status.Abstract
Introduction: Hematologic neoplasms, together with antineoplastic treatments, may lead to alterations in body composition, increasing the risk of sarcopenia and compromising quality of life. Objective: To assess the association between sarcopenia and quality of life in hospitalized patients with hematologic neoplasms. Methods: This cross-sectional study included adult and older patients hospitalized at the Hospital das Clínicas da Universidade Federal de Pernambuco (Hospital das Clínicas of the Federal University of Pernambuco) in 2024, with a diagnosis of hematologic neoplasm. Demographic, clinical, nutritional, and quality-of-life variables were collected. Sarcopenia was diagnosed using low arm muscle circumference combined with low handgrip strength. Quality of life was assessed using the cancer-specific questionnaire Functional Assessment of Cancer Therapy – General (FACT-G), in which higher scores indicate better quality of life; patients in the lowest tertile were classified as having poorer quality of life. Results: The sample included 35 patients, with a mean age of 55.0 ± 15.8 years. Sarcopenia was identified in 28.6% of participants, while low quality of life was observed in 34.3%, with a median score of 72.0 points. Sarcopenia was associated with quality of life with borderline significance (p = 0.053). Conclusion: The presence of sarcopenia and low quality of life were relevant findings, highlighting the need for longitudinal studies with larger samples to achieve more robust conclusions about the role of sarcopenia in the quality of life of this population.
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Copyright (c) 2025 Larissa Cabral dos Santos, Marcella Campos Lima da Luz, Cláudia Porto Sabino Pinho, Aline Rafaelly Apolônio da Silva
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