Serum vitamin D levels are correlated with cholesterol and not with body composition in individuals with type 2 diabetes mellitus and overweight

Authors

  • Mauro Celso de Souza Universidade Federal de Santa Catarina, Programa de Residência Integrada Multiprofissional em Saúde. Florianópolis, SC, Brasil. https://orcid.org/0000-0003-4988-2879
  • Giovanna Mozzaquattro Nascimento Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Nutrição. Florianópolis, SC, Brasil. https://orcid.org/0000-0001-8472-3545
  • Júlia Pessini Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Nutrição. Florianópolis, SC, Brasil. https://orcid.org/0000-0002-9522-5629
  • Simone Vande Sande-Lee Universidade Federal de Santa Catarina, Departamento de Clínica Médica. Florianópolis, SC, Brasil. https://orcid.org/0000-0002-5592-1603
  • Marcelo Fernando Ronsoni Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Ciências Médicas. Florianópolis, SC, Brasil. https://orcid.org/0000-0003-1187-9842
  • Erasmo Benicio Santos de Moraes Trindade Universidade Federal de Santa Catarina, Departamento de Nutrição. Florianópolis, SC, Brasil.

DOI:

https://doi.org/10.12957/demetra.2025.84778

Keywords:

Diabetes Mellitus. Type 2. Overweight. Obesity. Vitamin D. Cholesterol.

Abstract

Introduction: vitamin D (25OHD) plays an important role in carbohydrate and lipid metabolism. Vitamin D deficiency is frequently found in individuals with metabolic disorders. It is necessary to identify how serum levels of 25OHD correlate with these indicators in individuals with type 2 diabetes mellitus (T2DM) and excess weight. Objective: to analyze the correlation between 25OHD and body composition, anthropometric, and biochemical indicators in individuals with T2DM and excess weight. Métodos: cross-sectional study conducted at the University Hospital of Florianópolis, Brazil, in individuals with T2DM and excess weight. Body composition was determined by dual-energy X-ray absorptiometry. Anthropometric data were measured by standardized techniques. Biomarkers were analyzed from a serum sample. The correlation between 25OHD and the outcomes was verified using Spearman's correlation. Results: 20 individuals with 35 to 75 years old, of which 55% were female. Preserved muscle compartments were observed according to the appendicular muscle mass index, along with a high percentage of body fat in both sexes. Fifty percent of the individuals had vitamin D deficiency and 75% used supplementation. An inverse correlation was observed between 25OHD and total cholesterol (r= -0.52; p= 0.02) and non-HDL-c (r= -0.47 p= 0.04). Conclusion: The 25OHD levels are associated with the lipid profile of individuals with type 2 diabetes and overweight, showing an inverse correlation.

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Published

2025-11-14

How to Cite

1.
de Souza MC, Mozzaquattro Nascimento G, Pessini J, Vande Sande-Lee S, Fernando Ronsoni M, Santos de Moraes Trindade EB. Serum vitamin D levels are correlated with cholesterol and not with body composition in individuals with type 2 diabetes mellitus and overweight. DEMETRA [Internet]. 2025 Nov. 14 [cited 2025 Nov. 23];20:e84778. Available from: https://www.e-publicacoes.uerj.br/demetra/article/view/84778

Issue

Vol. 20 (2025)

Section

Clinical Nutrition

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Copyright (c) 2025 Mauro Celso de Souza, Giovanna Mozzaquattro Nascimento, Júlia Pessini, Simone Vande Sande-Lee, Marcelo Fernando Ronsoni, Erasmo Benicio Santos de Moraes Trindade

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