Hyperinsulinemia as an associated factor with hypovitaminosis D in overweight children and adolescents

Authors

  • Mariana Rodrigues Barreiros da Silva Universidade do Estado do Rio de Janeiro, Instituto de Nutrição, Curso de Especialização em Terapia Nutricional. Rio de Janeiro, RJ, Brasil. https://orcid.org/0000-0002-0365-6860
  • Cecília Lacroix de Oliveira Universidade do Estado do Rio de Janeiro, Instituto de Nutrição, Departamento de Nutrição Aplicada. Rio de Janeiro, RJ, Brasil. https://orcid.org/0000-0002-6198-9559
  • Flávia dos Santos Barbosa Brito Universidade do Estado do Rio de Janeiro, Instituto de Nutrição, Departamento de Nutrição Social. Rio de Janeiro, RJ, Brasil. https://orcid.org/0000-0001-8476-8567
  • Paulo Collett-Solberg Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil. https://orcid.org/0000-0002-6831-8520
  • Isabel Rey Madeira Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. https://orcid.org/0000-0002-2287-5364
  • Beatriz Louise Costa Themístocles Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Programa de Pós-Graduação em Fisiopatologia Clínica e Experimental. Rio de Janeiro, RJ, Brasil. https://orcid.org/0000-0002-2352-9682
  • Fernanda Mussi Gazolla Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil. https://orcid.org/0000-0001-9519-8133

DOI:

https://doi.org/10.12957/demetra.2024.80351

Abstract

Introduction: Amongst children and adolescents, hypovitaminosis D has been associated with conditions such as obesity, insulin resistance, hypertension and metabolic syndrome. In Brazil, more data on the prevalence of hypovitaminosis D and its associated factors needs to be collected for the overweight population of children and adolescents. Objective: To describe the prevalence of hypovitaminosis D in overweight children and adolescents and to investigate its associated factors. Methods: This is a cross-sectional, descriptive and retrospective study that collected and analyzed data, between 2022 and 2023, from the medical records of 92 overweight individuals (5 to 12 years old) participating in a childhood obesity research clinic, regarding their biochemical, anthropometric, food consumption, physical activity and blood pressure profiles, among others, associated with serum 25(OH)D concentrations. The cut-off point for hypovitaminosis D was 25(OH)D values lower than 30 ng/ml. The Qui-square test, the Kruskal-Wallis test and the Spearman correlation were used to study the relationship between associated factors and hypovitaminosis D. Results: A prevalence of hypovitaminosis D was observed in 64.13% of the sample. There was also an association between the vitamin D profile and serum insulin levels (p-value = 0.009) and HOMA-IR (p-value = 0.025), as well as a negative correlation between serum 25(OH)D and serum insulin (ρ = - 0.300**) and HOMA-IR (ρ = - 0.275*). Conclusion: The data suggest that, in overweight children and adolescents, vitamin D deficiency is related to higher serum insulin and HOMA-IR values.

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Author Biographies

Mariana Rodrigues Barreiros da Silva, Universidade do Estado do Rio de Janeiro, Instituto de Nutrição, Curso de Especialização em Terapia Nutricional. Rio de Janeiro, RJ, Brasil.

Mestre em Ciências (PPGICS/ICICT/FIOCRUZ), Aluna do Curso de Especialização em Terapia Nutricional – Instituto de Nutrição – Universidade do Estado do Rio de Janeiro (TENUTRI/INU/UERJ), Rio de Janeiro, RJ, Brasil.

Cecília Lacroix de Oliveira, Universidade do Estado do Rio de Janeiro, Instituto de Nutrição, Departamento de Nutrição Aplicada. Rio de Janeiro, RJ, Brasil.

Doutora em Ciências (UNIFESP), Professora Associada do Departamento de Nutrição Aplicada – Instituto de Nutrição – Universidade do Estado do Rio de Janeiro (INU/UERJ), Rio de Janeiro RJ, Brasil.

Flávia dos Santos Barbosa Brito, Universidade do Estado do Rio de Janeiro, Instituto de Nutrição, Departamento de Nutrição Social. Rio de Janeiro, RJ, Brasil.

Doutora em Saúde Coletiva (UERJ), Professora Associada do Departamento de Nutrição Social – Instituto de Nutrição – Universidade do Estado do Rio de Janeiro (INU/UERJ), Rio de Janeiro, RJ, Brasil.

Paulo Collett-Solberg, Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Departamento de Medicina Interna. Rio de Janeiro, RJ, Brasil.

Doutor em Medicina (UFRJ), Professor Associado do Departamento de Medicina Interna – Faculdade de Ciências Médicas – Universidade do Estado do Rio de Janeiro (FCM/UERJ), Rio de Janeiro, RJ, Brasil.

Isabel Rey Madeira, Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Departamento de Pediatria. Rio de Janeiro, RJ, Brasil.

Doutora em Ciências Médicas (PGCM/FCM/UERJ), Professora Associada do Departamento de Pediatria – Faculdade de Ciências Médicas – Universidade do Estado do Rio de Janeiro (FCM/UERJ), Rio de Janeiro, RJ, Brasil.

Beatriz Louise Costa Themístocles, Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Programa de Pós-Graduação em Fisiopatologia Clínica e Experimental. Rio de Janeiro, RJ, Brasil.

Especialista em Terapia Nutricional em Pediatria (UFRJ), Mestranda em Fisiopatologia Clínica e Experimental pelo Programa de Pós-graduação em Fisiopatologia Clínica e Experimental da Universidade do Estado do Rio de Janeiro (PPG-FISCLINEX/UERJ), Rio de Janeiro, RJ, Brasil.

Fernanda Mussi Gazolla, Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil.

Mestre em Ciências Médicas (PGCM/FCM/UERJ), Médica Endocrinologista da UDA de Endocrinologia e Metabologia do Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro (HUPE/UERJ), Rio de Janeiro, RJ, Brasil.

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Published

2024-10-14

How to Cite

1.
Rodrigues Barreiros da Silva M, Lacroix de Oliveira C, dos Santos Barbosa Brito F, Collett-Solberg P, Rey Madeira I, Louise Costa Themístocles B, et al. Hyperinsulinemia as an associated factor with hypovitaminosis D in overweight children and adolescents. DEMETRA [Internet]. 2024 Oct. 14 [cited 2025 May 1];19:e80351. Available from: https://www.e-publicacoes.uerj.br/demetra/article/view/80351

Issue

Vol. 19 (2024)

Section

Clinical Nutrition

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Copyright (c) 2024 Mariana Rodrigues Barreiros da Silva, Cecília Lacroix de Oliveira, Flávia dos Santos Barbosa Brito, Paulo Ferrez Collett-Solberg, Isabel Rey Madeira, Beatriz Louise Costa Themístocles, Fernanda Mussi Gazolla

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