Association between inflammatory markers, body composition and food consumption in children and adolescents
DOI:
https://doi.org/10.12957/demetra.2024.78102Abstract
Introduction: There is a relationship between inflammation and chronic non-communicable diseases, which generally manifest in adulthood. However, it is possible to detect inflammatory changes in children and young people. Thus, it is necessary to study the factors associated with inflammation in this life stage, so that adequate interventions can be made to stop such alterations from prolonging into adulthood. Objective: To assess the association between inflammatory markers, overweight indicators and food consumption markers in children and adolescents. Methods: Transversal study with 8- to 14-year-old individuals, from public schools in Vitória/ES. To assess inflammation, we used leukocytes, C-reactive protein, and uric acid. As overweight indicators, we used waist circumference, waist-to-height ratio, BMI-for-age, and body fat percentage. To estimate the likelihood of association, we calculated
prevalence ratios and their respective 95% confidence intervals using Poisson regression models, modified for sociodemographic characteristics. Results: We evaluated 296 individuals, averaging 10.7 years of age, 54.4% female, and 53.7% adolescents. All variables at risk of overweight indicators were significant with the risk of high uric acid, in addition to the risk of increasing waist-to-height ratio (PR = 1.14), BMI-for-age (PR = 1.08), and body fat (PR = 1.10) being significant with the risk of high CRP. Conclusion: We conclude that the risk of alterations in overweight indicators was related with the risk of increased inflammatory markers in school-aged individuals.
References
Batista Filho M, Rissin A. A transição nutricional no Brasil: tendências regionais e temporais. Cad Saúde Pública [Internet]. 2003;19 (suppl 1):S181–91. https://doi.org/10.1590/S0102-311X2003000700019
World Health Organization [Internet]. Obesityandoverweight. 2021. Geneva: WHO; [cited 2024 Jan 31]. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
Instituto Brasileiro de Geografia e Estatística. Pesquisa de Orçamentos Familiares 2008-2009 – POF. Antropometria e estado nutricional de crianças, adolescentes e adultos no Brasil. Rio de Janeiro, RJ 2010.
Geraldo JM, Alfenas R de CG. Papel da dieta na prevenção e no controle da inflamação crônica: evidências atuais. Arq Bras Endocrinol Metab [Internet]. 2008;52(6)):951–67. https://doi.org/10.1590/S0004-27302008000600006
Godinho AS, Gonçalves NH, Aguiar FS, Junior RFS, Bauman JM, Bauman CD. Principais Fatores Relacionados ao Sobrepeso e Obesidade Infantil. RENEF [Internet]. 21º de janeiro de 2020 [Acesso 3 Fev 2022];9(13):27-39. Disponível em: https://cev.org.br/biblioteca/principais-fatores-relacionados-ao-sobrepeso-e-obesidade-infantil/ https://doi.org/10.35258/rn2019091300028
Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose TissueRemodeling: Its Role in Energy Metabolism and Metabolic Disorders. Front. Endocrinol. 2016 Apr12;(7). https://doi.org/10.3389/fendo.2016.00030. PMID: 27148161
Battineni G, Sagaro GG, Chintalapudi N, Amenta F, Tomassoni D, Tayebati SK. Impact of Obesity-Induced Inflammation on Cardiovascular Diseases (CVD). Int J Mol Sci. 2021 Apr 30;22(9):4798. https://doi.org/10.3390/ijms22094798. PMID: 33946540
Volp ACP, Bressan J. Os biomarcadores ácido úrico, ácido siálico e leucócitos como preditores da síndrome metabólica. Revista Brasileira de Nutrição Clínica, 2011;(26):197-201.
Orlando A, Cazzaniga E, Giussani M, Palestini P, Genovesi S. Hypertension in Children: Role of Obesity, Simple Carbohydrates, and Uric Acid. Front Public Health. 2018 May 3;6:129. https://doi.org/10.3389/fpubh.2018.00129. PMID: 29774210
Kimura Y, Yanagida T, Onda A, Tsukui D, Hosoyamada M, Kono H. Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):570-582. https://doi.org/10.1161/ATVBAHA.119.313224. PMID: 31996020.
Siervo M, Ruggiero D, Sorice R, Nutile T, Aversano M, Iafusco M, et al. Body mass index is directly associated with biomarkers of angiogenesis and inflammation in children and adolescents. Nutrition, March 2012: 28(3):262-266. https://doi.org/10.1016/j.nut.2011.06.007
Bogea EG, Martins MLB, Carmo CDS, Nascimento JXPT, Arruda SPM, Ribeiro CCC, et al. Fatores associados aos biomarcadores inflamatórios em adolescentes: análise por modelagem de equações estruturais. Cadernos de Saúde Pública [online]. 2021;37(11) [Acesso 4 Jul 2022] ,e00212220. https://doi.org/10.1590/0102-311X00212220>.
Bernardo FMS, Rouberte ESC, Leal FKF, Meirú MIL, Ferreira JDF, Ferreira, DS. Educação em saúde para aspectos nutricionais como forma de prevenir alterações cardiovasculares: relato de experiência. Rev. enferm UFPE online 2017;11(2):765-777. https://doi.org/10.5205/reuol.10263-91568-1-RV.1102201734
Matias NCM, França AKTC, Conceição SIO, Santos AM, Alencar J Daniel, Carmo CDS, et al. Nutritional status, diet quality and inflammatory markers in adolescents. Archivos Latinoamericanos de Nutrición [Internet]. [Acesso 4 Jul 2022], 2020 Sep 12;70(4). Available from: https://www.alanrevista.org/ediciones/2020/4/art-1/# https://doi.org/10.37527/2020.70.4.001.
Neves FS, Alvim R de O, Zaniqueli D, Pani VO, Martins CR, Peçanha MA de S, et al..Tri-ponderal mass index is useful for screening children and adolescents with insulin resistance. Rev paul pediatr [Internet]. 2020;38. https://doi.org/10.1590/1984-0462/2020/38/2019066
Afiune Neto A, Mansur A de P, Avakian SD, Gomes EPSG, Ramires JAF. Monocitose é um marcador de risco independente para a doença arterial coronariana. Arq Bras Cardiol [Internet]. 2006 Mar;86(3):240-4 https://doi.org/10.1590/S0066-782X2006000300013
Lohman T, Roche A, Martorell E. Manual de referência de padronização antropométrica. Champaign: Livros de Cinética Humana; 1988 - Human Kinetics Books, Champaign, IL, ©1988. [Google Acadêmico]
De Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ. 2007 Sep;85(9):660-7. https://doi.org/10.2471/blt.07.043497. PMID: 18026621
World Health Organization . Library Cataloguing-in-Publication Data Waist circumference and waist–hip ratio: report of a WHO expert consultation. Geneva: World Health Organization; December 2008:8-11.
Ashwell M, Hsieh SD. Six reasons why the waist-to-heigh tratiois a rapidand effective global indicator for health risks of obesity and how its use could simplify the international public health message on obesity. Int J Food Sci Nutr. 2005 Aug;56(5):303-7. https://doi.org/10.1080/09637480500195066. PMID: 16236591.
Moulin-Mares SRA, Oliosa PR, Faria ER, Zago-Gomes MP, Mill JG. Association of uricacid with cardiovascular risk in Brazilian children and adolescents. Nutr Metab Cardiovasc Dis. 2021 Jan 4;31(1):314-321. https://doi.org/10.1016/j.numecd.2020.09.012. PMID: 33223404.
Freedman DS, Wang J, Thornton JC, Mei Z, Sopher AB, Pierson RN Jr, et al. Classification of body fatness by body mass index-for-age categories among children. Arch Pediatr Adolesc Med. 2009 Sep;163(9):805-11. https://doi.org/10.1001/archpediatrics.2009.104. PMID: 19736333
Assis MAA, Benedet J, Kerpel R, Vasconcelos FAG, Di Pietro PF, Kupek E. Validação da terceira versão do Questionário Alimentar do Dia Anterior (QUADA-3) para escolares de 6 a 11 anos. Cadernos de Saúde Pública [online]. 2009;25(8):1816-1826. [Acesso 24 Jun 2022]. https://doi.org/10.1590/S0102-311X2009000800018.
Instituto Brasileiro de Geografia e Estatística. Metodologia do Censo Demográfico 2010. 2. ed. Rio de Janeiro: IBGE;2016.
Associação Brasileira de Empresas de Pesquisa. Critério Brasil 2015 e atualização da distribuição de classes para 2016. [Acesso 24 Jun 2022]. Disponível em: .
Yi Q, Li X, He Y, Xia W, Shao J, Ye Z, Song P. Associations of dietary inflammatory index with metabolic syndrome and its components: a systematic review and meta-analysis. Public Health Nutr. 2021 Nov;24(16):5463-5470. https://doi.org/10.1017/S1368980021000288. PMID: 33472715
Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota controlmetabolicendotoxemia-inducedinflammation in high-fat diet-inducedobesityand diabetes in mice. Diabetes. 2008 Jun;57(6):1470-81. https://doi.org/10.2337/db07-1403. PMID: 18305141
Lucas M, Chocano-Bedoya P, Schulze MB, Mirzaei F, O'Reilly ÉJ, Okereke OI, Hu FB, Willett WC, Ascherio A. Inflammatory dietary pattern and risk of depression among women. Brain BehavImmun. 2014 Feb;36:46-53. https://doi.org/10.1016/j.bbi.2013.09.014. Epub 2013 Oct 1. Erratum in: Brain BehavImmun. 2015 May;46:327. Shulze, Mathias B [corrected to Schulze, Matthias B]. PMID: 24095894; PMCID: PMC3947176.
Choi J, Joseph L, Pilote L. Obesity and C-reactiveprotein in various populations: a systematic review and meta-analysis. Obes Rev. 2013 Mar;14(3):232-44. https://doi.org/10.1111/obr.12003. PMID: 23171381
Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, et al. Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents. J Clin Endocrinol Metab. 2020 Apr 1;105(4):e1781–97. https://doi.org/10.1210/clinem/dgz161. PMID: 31845996
Cardoso AS, Gonzaga NC, Medeiros CCM, Carvalho DF de. Relação entre ácido úrico e os componentes da síndrome metabólica e esteatose hepática não alcoólica em crianças e adolescentes com sobrepeso ou obesidade. J Pediatr (Rio J) [Internet]. 2013 Jul;89(4):412–8. https://doi.org/10.1016/j.jped.2012.12.008
Luciano R, Shashaj B, Spreghini M, Del Fattore A, Rustico C, Sforza RW, Morino GS, Dallapiccola B, Manco M. Percentiles of serum uric acid and cardiometabolic abnormalities in obese Italian children and adolescents. Ital J Pediatr. 2017 Jan;43(3) https://doi.org/10.1186/s13052-016-0321-0. PMID: 28049502
Tsushima Y, Nishizawa H, Tochino Y, Nakatsuji H, Sekimoto R, Nagao H, et al. Uricacid secretion from adipose tissue and its increase in obesity. J Biol Chem. 2013 Sep 20;288(38):27138-27149. https://doi.org/10.1074/jbc.M113.485094. PMID: 23913681
Leone C, Nascimento VG, Silva JPC, Bertoli CJ. Razão cintura/estatura: marcador de alteração nutricional em pré-escolares. Rev. bras. crescimento desenvolv. [Acesso 24 Jun 2022], 2014;24(3):289-294. Disponível em: <http://pepsic.bvsalud.org/scielo.php?script=sci_arttext&pid=S0104-12822014000300008&lng=pt&nrm=iso>. https://doi.org/dx.doi.org/10.7322/jhdg.88962
Caminiti C, Armeno M, Mazza CS. Waist-to-heightratio as a markeroflow-grade inflammation in obese children and adolescents. J Pediatr Endocrinol Metab. 2016 May 1;29(5):543-51. https://doi.org/: 10.1515/jpem-2014-0526. PMID: 26887032.
Menni C, Louca P, Berry SE, Vijay A, Astbury S, Leeming ER, et al. High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome. BMC Med. 2021 Feb 11;19(1):37. https://doi.org/10.1186/s12916-021-01913-w. PMID: 33568158
Badimon L, Suades R, Crespo J, Padro T, Chiva-Blanch G. Diet, micro particles and atherothrombosis. Front Biosci (Landmark Ed). 2018 Jan 1;23(3):432-457. https://doi.org/10.2741/4598. PMID: 28930554.
Mc Geoghegan L, Muirhead CR, Almoosawi S. Association between ananti-inflammatory and anti-oxidant dietary pattern and diabetes in British adults: results from the national diet and nutrition survey rolling programme years 1-4. Int J FoodSciNutr. 2015;67(5):553-61. https://doi.org/10.1080/09637486.2016.1179268
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Julia Souza Siqueira de Andrade, Alan Roger José Maria, Felipe Silva Neves, Maria Eduarda Ribeiro de Jesus, Miriam Carmo Rodrigues Barbosa, Eliane Rodrigues de Faria
This work is licensed under a Creative Commons Attribution 4.0 International License.
STATEMENT OF AUTHORSHIP RESPONSIBILITY
Title of the manuscript:
________________________________________________________
1. Statement of responsability
I certify that I have participated in the work above specified and take public responsibility for its content.
I certify that the manuscript represents an original work and that none of the material in the manuscript has been previously published, is included in another manuscript, or is currently under consideration for publication elsewhere, whether in printed form or in electronic media, except that described in the attachment.
In case of acceptance of this text by Demetra: Alimentação, Nutrição & Saude, I declare to be in accordance with the policy of public access and copyright adopted by Demetra, which provides as follows: (a) the authors retain the copyright and grant to the Journal the right of first publication, the work being simultaneously licensed under the Creative Commons Attribution License, which allows the sharing of the work with acknowledgment of authorship and initial publication in this journal; (b) authors are authorized to enter additional contracts separately for non-exclusive distribution of the version of the work published in this journal (eg, publishing in institutional repository or book chapter), with acknowledgment of authorship and initial publication in this journal; and (c) authors are permitted and encouraged to post and distribute their work online (eg, in institutional repositories or on their personal page) at any point before or during the editorial process, as this may lead to productive changes, as well as increase the impact and citation of the published work.
2. Conflict of Interest Statement
I certify that there is no conflict of interest in connection with the submitted article.
Date, signature and full address of all authors.