Consumo de Castanha-do-Brasil reduz o N-óxido de trimetilamina (TMAO) e a inflamação em um paciente com síndrome cardiorrenal: uma comunicação breve

Karen Salve Coutinho Wolino; Beatriz Oliveira da Cruz; Ludmila Ferreira Medeiros de França Cardozo; Claudio Tinoco Mesquita; Denise Mafra; Milena Barcza Stockler-Pinto

doi:10.12957/demetra.2023.73690

Autores

Karen Salve Coutinho Wolino Universidade Federal Fluminense http://orcid.org/0000-0002-2489-1237
Beatriz Oliveira da Cruz http://orcid.org/0000-0002-3169-9315
Ludmila Ferreira Medeiros de França Cardozo http://orcid.org/0000-0001-8507-2369
Claudio Tinoco Mesquita http://orcid.org/0000-0002-1466-9413
Denise Mafra http://orcid.org/0000-0001-6752-6056
Milena Barcza Stockler-Pinto http://orcid.org/0000-0003-0131-2033

DOI:

https://doi.org/10.12957/demetra.2023.73690

Palavras-chave:

Síndrome cardiorrenal. N-óxido de Trimetilamina. Inflamação. Castanha-do-Brasil.

Resumo

Introdução: A disbiose intestinal é uma característica comum na síndrome cardiorrenal e está associada ao aumento de toxinas urêmicas, como o N-óxido de trimetilamina (TMAO), que estão envolvidas com a inflamação e mortalidade cardiovascular. A castanha-do-Brasil (semente típica brasileira) possui propriedades anti-inflamatórias e antioxidantes, mas não há evidências dos seus efeitos na modulação da microbiota intestinal e redução de toxinas urêmicas. Objetivo: Avaliar o impacto do consumo de castanha-do-Brasil nos níveis de TMAO e marcadores de inflamação em um paciente com síndrome cardiorrenal. Métodos: Um paciente com doença arterial coronariana (66 anos e IMC, 26 kg/m2), estágio 3 da DRC (TFGe 36 mL/min), recebeu uma castanha-do-Brasil por dia durante três meses. Resultados: Os níveis plasmáticos de TMAO e a expressão de mRNA de NF-κB foram reduzidos e a atividade da glutationa peroxidase (GPx) aumentou após esta intervenção. Conclusão: A prescrição de castanha-do-Brasil pode ser uma estratégia promissora para mitigar as complicações relacionadas à síndrome cardiorrenal. Este caso apoia o conceito de “alimento como remédio” visando o fenótipo urêmico na síndrome cardiorrenal.

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Consumo de Castanha-do-Brasil reduz o N-óxido de trimetilamina (TMAO) e a inflamação em um paciente com síndrome cardiorrenal: uma comunicação breve

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