LEPTIN, GHRELIN AND ADIPONECTIN IN LACTATING ADOLESCENT MOTHERS AND THEIR RELATIONSHIP WITH BODY COMPOSITION OF THE MOTHER AND BABY
DOI:
https://doi.org/10.12957/demetra.2014.10833Abstract
The hormones ghrelin, leptin and adiponectin are related to body weight control and to energymetabolism, and may also be involved with maternal body composition changes during lactation. Ghrelin,leptin and adiponectin are present in human milk and may also play a role in the infant energy metabolismin the first months of life. The aim of this study was to determine blood concentrations of leptin, ghrelinand adiponectin in lactating adolescents and investigate its correlation with milk concentrations of thesehormones and with body composition of the mother and their infants. Fifty five lactating adolescents (14 -19 years old) were enrolled at the “Maternidade Escola UFRJ” health care. Maternal Blood and maternalmilk samples were collected after overnight fasting. Anthropometric evaluation and body compositionassessment using Dual-Energy X-Ray absorptiometry (DXA) were performed in the lactating mother andtheir infants (10-58 days postpartum). Blood and milk concentrations of ghrelin, leptin and adiponectinwere analyzed by enzymatic immunoassay (ELISA). Kolmogorov-Smirnov test was used to verify thenormality distribution of data, which were presented as mean ± standard deviation. Associations betweenvariables were evaluated using Pearson’s correlation analysis. Additionally, associations involving infant bodycomposition were also investigated after adjustments for postpartum period by partial correlation analysis.Concentrations of leptin, ghrelin and adiponectin in milk (0,51±0,4 ng/mL,106±80 pg/mL, 0,11±0,69μg/mL respectively) were lower (p<0.05) than in maternal blood (17,8±11,9 ng/mL, 557±392 pg/mL, 5,9±2,5 μg/mL respectively). Leptin in maternal serum correlated significantly with leptin concentrations inmilk (r=0,38;p=0,01). Maternal serum leptin was also significantly (p<0,05) associated with maternal totalbody mass (r=0,47), BMI (r=0,46) and percent of fat mass (r=0,56). Leptin concentration in breast milkwas significantly (p<0,05) associated with maternal total body mass (r=0,43), BMI (r=0,35) and percentfat mass (r= 0,54). Adiponectin concentration in breast milk was positively associated with pre-pregnancyBMI (r=0,31; p<0,05) and percent fat mass (r=0,23; p<0.05). After adjustments for postpartum period,infant total body fat mass (r=0,43) and percent fat mass (r=0,39) were positively associated with leptinconcentration in breast milk (p<0.05). Also, infant body weight (r=-0,41), total body fat mass (r=-0,34) andpercent fat mass (r=-0,30) were negatively associated with milk ghrelin (p<0.05). These results suggest that leptin concentration on breast milk may be involved in the regulation of infant body composition in the firstmonths of life. Breast milk leptin concentration appears to be modulated by maternal body composition.We also observed that milk ghrelin may influence infant fat mass in the postpartum period, independentlyof mother’s body composition.
DOI 10.12957/demetra.2014.10833
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