Vitamin D levels and risk of COVID-19 infection: A systematic review
DOI:
https://doi.org/10.12957/bjhbs.2020.59708Palavras-chave:
Vitamin D, COVID-19, Public health.Resumo
Objective: Consistent independent associations between low
serum 25-hydroxyvitamin D concentrations and susceptibility
to acute respiratory tract infections have suggested a
possible involvement of vitamin D in reducing the risk of
respiratory infections and proposing its replacement as a
potential strategy for prevention or treatment in this context.
However, the role of vitamin D supplementation in the
infection by the novel coronavirus named SARS-CoV-2 is
still under investigation and no clinical evidence has been
reported to date. Methods: Electronic searches in Pubmed,
Embase and Scopus databases were conducted and three
cohort studies that analyzed the effects of interaction of
vitamin D with COVID-19, published only in English, were
included. Two reviewers, which independently examined
titles and abstracts, identified records through database search
and reference screening and irrelevant studies were excluded
based in eligibility criteria. Relevant full texts were analyzed
for eligibility, and all relevant studies were included in the
systematic review. Results: Three cohort studies were included
in this systematic review with a mean methodological
quality low. Only one study demonstrated interaction of low
vitamin D concentration in patients with a positive diagnosis
for COVID-19. Randomized clinical trials and studies of good
methodological quality are necessary to confirm the findings
of this systematic review. Conclusions: This systematic review
has not demonstrated consistent associations between low
levels of vitamin D and susceptibility to COVID-19 infection.
Further studies on vitamin D supplementation for the prevention
of COVID-19 infection should be conducted..
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