Multiresistance and endemic status of Corynebacterium striatum associated with nosocomial infections: a critical situation in Intensive Care Units and varied wards of a tertiary care hospital, Rio de Janeiro metropolitan area, Brazil
DOI:
https://doi.org/10.12957/bjhbs.2021.63963Keywords:
Corynebacterium striatum, Multidrug resistance, nosocomial infections, virulence, endemic.Abstract
Nowadays, Corynebacterium striatum has been reported as
etiologic agent of mild to severe hospital-acquired infections,
including patients undergoing endotracheal intubation with
fatal outcome. A continuous survey of infections due multidrug-
resistant (MDR) C. striatum in South American countries
remains necessary. This retrospective and prospective study
aimed to analyze clinical-microbiological features of C. striatum
clinical isolates from patients attended at a Brazilian
tertiary care hospital, during a nine-year period. C. striatum
strains (n=130) were isolated from infected patients attended at
twenty nosocomial wards, mainly of tracheal aspirate (n=53)
and blood and/or intravenous catheter (n=21/n=13). Notably,
original cases of nosocomial infections due to C. striatum were
verified in children making use of invasive devices, including
one fatal neonatal case, in addition to a fatal respiratory
infection in patient with cystic fibrosis, as well as urinary
tract infections of kidney transplant recipients. Most of C.
striatum strains expressed MDR profiles (88.46%). Emergence
of vancomycin (1.90%) and linezolid (7.41%) resistance was
verified among MDR and non-MDR-strains. In conclusion,
endemic condition with wide dissemination among hospital
wards of varied types of infections due to MDR and non-MDR
C. striatum strains expressing heterogenic virulence potential
and genetic features may occur in hospital units.
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