Pulmonary and central nervous system infiltration of chronic lymphocytic leukemia with concomitant diffuse large B-cell lymphoma: Case report and review of literature
DOI:
https://doi.org/10.12957/bjhbs.2020.59716Keywords:
Chronic lymphoid leukemia (CLL), Diffuse large B-cell lymphoma (DLBCL), Central Nervous System infiltration, Pulmonary infiltration.Abstract
Introduction: Diffuse large B-cell lymphoma (DLBCL) and
chronic lymphoid leukemia (CLL) are lymphoproliferative
diseases of B lymphocytes. Objective: To describe the concomitance
of diseases with pulmonary and CNS involvement.
Clinical case: A 67-year-old patient with DLBCL and CLL
obtained partial remission of the diseases after six cycles of
standard combined chemotherapy. Relapse of CLL (del17p;
TP53+) occurred after 22 months, becoming refractory to a
new treatment. Monoclonal B lymphocyte infiltration was
found in the cerebrospinal fluid and bronchoalveolar lavage,
leading to death due to respiratory failure. Conclusion: The
unfavorable outcome shows a rare and serious complication
in the concomitance of these diseases.
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