Pulmonary and central nervous system infiltration of chronic lymphocytic leukemia with concomitant diffuse large B-cell lymphoma: Case report and review of literature

Authors

  • Saulo F. D. Batista Medical Clinic Service, Pedro Ernesto University Hospital, Rio de Janeiro State University (UERJ). Rio de Janeiro, Brazil. https://orcid.org/0000-0001-8223-932X
  • Karina V. de Melo Hematology Service, Pedro Ernesto University Hospital, Rio de Janeiro State University (UERJ). Rio de Janeiro, Brazil.
  • Patricia Horn Hematology Service, Pedro Ernesto University Hospital, Rio de Janeiro State University (UERJ). Rio de Janeiro, Brazil.
  • Vinicius da C. Lisboa Department of General Pathology, Faculty of Medical Sciences. Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil.
  • Ana Sheila Cypriano Department of General Pathology, Faculty of Medical Sciences. Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil.
  • Andrea Pires Fonte Medicina Diagnóstica Laboratory. Niterói, Brazil.
  • Marilza de M. Ribeiro-Carvalho Department of General Pathology, Faculty of Medical Sciences. Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil.
  • Fábio Santiago Department of General Pathology, Faculty of Medical Sciences. Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil.
  • Maria Helena F. O. de Souza Department of General Pathology, Faculty of Medical Sciences. Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil. Postgraduate Program in Medical Sciences (PGCM), Rio de Janeiro State University (UERJ). Rio de Janeiro, Brazil.

DOI:

https://doi.org/10.12957/bjhbs.2020.59716

Keywords:

Chronic lymphoid leukemia (CLL), Diffuse large B-cell lymphoma (DLBCL), Central Nervous System infiltration, Pulmonary infiltration.

Abstract

Introduction: Diffuse large B-cell lymphoma (DLBCL) and
chronic lymphoid leukemia (CLL) are lymphoproliferative
diseases of B lymphocytes. Objective: To describe the concomitance
of diseases with pulmonary and CNS involvement.
Clinical case: A 67-year-old patient with DLBCL and CLL
obtained partial remission of the diseases after six cycles of
standard combined chemotherapy. Relapse of CLL (del17p;
TP53+) occurred after 22 months, becoming refractory to a
new treatment. Monoclonal B lymphocyte infiltration was
found in the cerebrospinal fluid and bronchoalveolar lavage,
leading to death due to respiratory failure. Conclusion: The
unfavorable outcome shows a rare and serious complication
in the concomitance of these diseases.

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Published

2021-05-07

How to Cite

1.
Batista SFD, de Melo KV, Horn P, Lisboa V da C, Cypriano AS, Pires A, et al. Pulmonary and central nervous system infiltration of chronic lymphocytic leukemia with concomitant diffuse large B-cell lymphoma: Case report and review of literature. BJHBS [Internet]. 2021 May 7 [cited 2025 May 25];19(2):124-9. Available from: https://www.e-publicacoes.uerj.br/bjhbs/article/view/59716

Issue

Vol. 19 No. 2 (2020)

Section

Literature Review

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