Diabetic pneumopathy: A study of induced sputum and pulmonary function in patients with type 2 diabetes mellitus

Authors

  • Rogério M. Bártholo Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.
  • Elizabeth Bessa Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.
  • Thiago P. Bártholo Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.
  • Cláudia Henrique da Costa Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.
  • Agnaldo José Lopes Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.
  • Rogério Rufino Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

DOI:

https://doi.org/10.12957/bjhbs.2019.53509

Abstract

Objective: To evaluate the cellularity, and albumin and interleukin
(IL)-1 levels in induced sputum (IS), and to determine
respiratory function parameters in patients with type 2 diabetes
mellitus (DM2). Design: A cross-section study in type 2
diabetes mellitus. Participants: Patients with type 2 diabetes
mellitus and healthy people. Methods: Patients in both groups
had normal chest x-ray findings. Exclusion criteria for both
groups were: the presence of current pulmonary disease or
sequelae, smoking, respiratory atopy, or respiratory infection
in the past 3 months. The study consisted of two sub-studies.
In sub-study 1 (SS1), measurements of pulmonary volume and
flow, and diffusion capacity for carbon monoxide (DLCO) were
performed. In sub-study 2 (SS2), analysis of cellularity, albumin,
and IL-1 in IS was performed. Results: In all, 60 patients
(45 women, 75%) with DM2 with a mean age of 59.52 years (SD,
9.03) were included in SS1. The DM2 group included 8 patients
with airway obstruction (13.33%) without reversibility with
bronchodilators, and 9 with restrictive disease (15.00 %) (p =
0.026). The DLCO was reduced in 17 patients (28.33%) in the
DM2 group. In the control group, all individuals had values
within the reference intervals. Lymphocytosis was found in
the IS of patients with DM2 (p = 0.028). The levels of sputum
albumin showed no statistical difference between the two
groups. Conclusion: Our findings indicate the presence of
pulmonary impairment in DM2, characterized by changes in
the respiratory function and a lymphocytosis in IS.


Keywords: Diabetes mellitus type 2; Induced sputum;
Lymphocytes.

Author Biographies

Rogério M. Bártholo, Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

Elizabeth Bessa, Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

Thiago P. Bártholo, Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

Cláudia Henrique da Costa, Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

Agnaldo José Lopes, Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

Rogério Rufino, Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

Thoracic Disease Department. Medical Sciences Faculty. Rio de Janeiro State University. Rio de Janeiro, Brazil.

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Published

2019-12-04

How to Cite

Bártholo, R. M., Bessa, E., Bártholo, T. P., da Costa, C. H., Lopes, A. J., & Rufino, R. (2019). Diabetic pneumopathy: A study of induced sputum and pulmonary function in patients with type 2 diabetes mellitus. Brazilian Journal of Health and Biomedical Sciences, 18(2), 144–150. https://doi.org/10.12957/bjhbs.2019.53509

Issue

Vol. 18 No. 2 (2019)

Section

Original Papers

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