Diabetes mellitus and heart: a continuum of risk Contemporary targets of treatment and how to reach them?

Authors

  • Marília B. Gomes Disciplina de Diabetes e Metabologia. Departamento de Medicina Interna. Faculdade de Ciências Médicas. Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
  • Aline Tiemi K. Silva Faculdade de Ciências Médicas. Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
  • Pedro P. M. Spineti Disciplina de Cardiologia. Departamento de Clínica Médica. Faculdade de Medicina. Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.

DOI:

https://doi.org/10.12957/rhupe.2013.7080

Abstract

Revista HUPE, Rio de Janeiro, 2013;12(Supl 1):25-35

doi: 10.12957/rhupe.2013.7080

Cardiovascular diseases are the most prevalent cause of morbidity and mortality among patients with type 1 or type 2 diabetes. The proposed mechanisms for the increased cardiovascular risk (CV) in this population are poorly understood. It has been suggested that an association between hyperglycemia and intracellular metabolic changes can result in oxidative stress, low-grade inflammation, and endothelial dysfunction. Some clinical factors that may coexist with diabetes such as obesity, dyslipidemia, and hypertension are also important and may increase the CV risk of diabetes. The aim of this article is to discuss the continuous link between glucose control, oxidative stress, insulin resistance, and subclinical inflammation with CV risk. We discuss the estabilished treatment goals for the diabetic patient in the context of pharmacological and non-pharmacological therapeutics.

Keywords: Diabetes mellitus; Cardiovascular diseases; Hypertension; Blood glucose; Dyslipidemias; Therapeutics.

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Published

2013-08-20

Issue

Vol. 12 (2013): SUPLEMENTO 1: A cardiologia no século 21: uma visão multidisciplinar

Section

Artigos

License

<a rel="license" href="http://creativecommons.org/licenses/by-nc/4.0/"><img alt="Licença Creative Commons" style="border-width:0" src="https://i.creativecommons.org/l/by-nc/4.0/88x31.png" /></a><br /><span xmlns:dct="http://purl.org/dc/terms/" property="dct:title">Revista Hospital Universitário</span> de <a xmlns:cc="http://creativecommons.org/ns#" href="http://www.e-publicacoes.uerj.br/index.php/revistahupe/index" property="cc:attributionName" rel="cc:attributionURL">http://www.e-publicacoes.uerj.br/index.php/revistahupe/index</a> está licenciado com uma Licença <a rel="license" href="http://creativecommons.org/licenses/by-nc/4.0/">Creative Commons - Atribuição-NãoComercial 4.0 Internacional</a>.