Sarcopenia: uma revisão narrativa das definições

Autores

  • Virgílio G. Moreira Laboratório de Pesquisa em Envelhecimento Humano - GeronLab. Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil
  • Roberto A. Lourenço Departamento de Medicina Interna. Hospital Universitário Pedro Ernesto. Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.

DOI:

https://doi.org/10.12957/rhupe.2017.37660

Resumo

Introdução: A sarcopenia é uma condição clínica associada ao envelhecimento. Está diretamente relacionada com desfechos indesejáveis à população idosa. Tem grande potencial terapêutico e apresenta elevada prevalência, de acordo com os critérios diagnósticos adotados. Objetivos: Realizar uma revisão sobre as principais definições de sarcopenia utilizadas em estudos epidemiológicos. Métodos: Trata-se de uma revisão narrativa com foco na busca de publicações sobre o tema utilizando palavras-chave por meio de linguagens boleanas via Medical Subheadings no PubMed: “sarcopenia”, “diagnosis”, “aged” e “epidemiology”. Do total de 1058 citações, 14 foram selecionadas. Resultados: Os trabalhos analisados apresentam uma perspectiva histórica da sarcopenia englobando sua definição original – somente massa muscular – até os trabalhos subsequentes que agregaram força e, posteriormente, desempenho funcional aos seus critérios diagnósticos. Conclusões: Apesar dos trabalhos mais recentes identificarem a associação dos três critérios para definição de sarcopenia – massa, força muscular e desempenho funcional – são necessários outros estudos para verificar o melhor constructo para esta condição clínica, uma vez que o critério original ainda é utilizado nesta definição.
Descritores: Sarcopenia; Idosos; Diagnóstico.

Biografia do Autor

Virgílio G. Moreira, Laboratório de Pesquisa em Envelhecimento Humano - GeronLab. Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil

Laboratório de Pesquisa em Envelhecimento Humano - GeronLab. Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil

Roberto A. Lourenço, Departamento de Medicina Interna. Hospital Universitário Pedro Ernesto. Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.

Departamento de Medicina Interna. Hospital Universitário Pedro Ernesto. Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.

Referências

World Health O. World report on ageing and health. Geneva, Switzerland: World Health Organization; 2015.

IBGE. Síntese de indicadores sociais: uma análise das condições de vida da população brasileirea. Rio de Janeiro: IBGE; 2015.

Canedo AC, Lopes CS, Lourenco RA. Prevalence of and factors associated with successful aging in Brazilian older adults: Frailty in Brazilian older people Study (FIBRA RJ). Geriatr Gerontol Int. 2018.

Moreira VG, Lourenco RA. Prevalence and factors associated with frailty in an older population from the city of Rio de Janeiro, Brazil: the FIBRA-RJ Study. Clinics (Sao Paulo). 2013;68(7):979-85.

Cesari M, Marzetti E, Thiem U, Perez-Zepeda MU, Abellan Van Kan G, Landi F, et al. The geriatric management of frailty as paradigm of “The end of the disease era”. Eur J Case Rep Intern Med. 2016;31:11-4.

Rizzoli R, Reginster JY, Arnal JF, et al. Quality of life in sarcopenia and frailty. Calcif Tissue Int. 2013;93(2):101-20.

Inouye SK, Studenski S, Tinetti ME, et al. Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc. 2007;55(5):780-91.

Wu CH, Yang KC, Chang HH, et al. Sarcopenia is related to increased risk for low bone mineral density. J Clin Densitom. 2013;16(1):98-103.

Woo J, Leung J, Sham A, Kwok T. Defining sarcopenia in terms of risk of physical limitations: a 5-year follow-up study of 3,153 chinese men and women. J Am Geriatr Soc. 2009;57(12):2224-31.

Weber J, Gillain S, Petermans J. [Sarcopenia: a physical marker of frailty]. Rev Med Liege. 2010;65(9):514-20.

Visser M. Obesity, sarcopenia and their functional consequences in old age. Proc Nutr Soc. 2011;70(1):114-8.

Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr. 1997;127(5 Suppl):990S-1S.

Rosenberg IH. Sarcopenia: origins and clinical relevance. Clin Geriatr Med. 2011;27(3):337-9.

Cederholm TE, Bauer JM, Boirie Y, et al. Toward a definition of sarcopenia. Clin Geriatr Med. 2011;27(3):341-53.

Fantin F, Di Francesco V, Fontana G, et al. Longitudinal body composition changes in old men and women: interrelationships with worsening disability. J Gerontol A Biol Sci Med Sci. 2007;62(12):1375-81.

Koster A, Ding J, Stenholm S, Caserotti P, et al. Does the amount of fat mass predict age-related loss of lean mass, muscle strength, and muscle quality in older adults? J Gerontol A Biol Sci Med Sci. 2011;66(8):888-95.

Frontera WR, Hughes VA, Fielding RA, et al. Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol. 2000;88(4):1321-6.

Delmonico MJ, Harris TB, Visser M, et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr. 2009;90(6):1579-85.

Curcio F, Ferro G, Basile C, et al. Biomarkers in sarcopenia: A multifactorial approach. Exp Gerontol. 2016;85:1-8.

Bijlsma AY, Meskers CG, Westendorp RG, et al. Chronology of age-related disease definitions: osteoporosis and sarcopenia. Ageing Res Rev. 2012;11(2):320-4.

Dhillon RJ, Hasni S. Pathogenesis and Management of Sarcopenia. Clin Geriatr Med. 2017;33(1):17-26.

Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998;147(8):755-63.

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412-23.

Melton LJ, 3rd, Khosla S, Crowson CS, et al. Epidemiology of sarcopenia. J Am Geriatr Soc. 2000;48(6):625-30.

Delmonico MJ, Harris TB, Lee JS, et al. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc. 2007;55(5):769-74.

Janssen I, Heymsfield SB, Baumgartner RN, et al. Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol (1985). 2000;89(2):465-71.

Visser M, Deeg DJ, Lips P, et al. Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women. J Am Geriatr Soc. 2000;48(4):381-6.

Sowers MR, Crutchfield M, Richards K, et al. Sarcopenia is related to physical functioning and leg strength in middle-aged women. J Gerontol A Biol Sci Med Sci. 2005;60(4):486-90.

Hairi NN, Cumming RG, Naganathan V, et al. Loss of muscle strength, mass (sarcopenia), and quality (specific force) and its relationship with functional limitation and physical disability: the Concord Health and Ageing in Men Project. J Am Geriatr Soc. 2010;58(11):2055-62.

Goodpaster BH, Park SW, Harris TB, et al. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci. 2006;61(10):1059-64.

Landi F, Liperoti R, Fusco D, et al. Prevalence and risk factors of sarcopenia among nursing home older residents. J Gerontol A Biol Sci Med Sci. 2012;67(1):48-55.

Abellan van Kan G, Andre E, Bischoff Ferrari HA, et al. Carla Task Force on Sarcopenia: propositions for clinical trials. J Nutr Health Aging. 2009;13(8):700-7.

Fielding RA, Vellas B, Evans WJ, et al. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc. 2011;12(4):249-56.

Muscaritoli M, Anker SD, Argiles J, et al. Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”. Clin Nutr. 2010;29(2):154-9.

Chen LK, Liu LK, Woo J, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc. 2014;15(2):95-101.

Young A, Stokes M, Crowe M. The size and strength of the quadriceps muscles of old and young men. Clin Physiol. 1985;5(2):145-54.

Heymsfield SB, McManus C, Smith J, et al. Anthropometric measurement of muscle mass: revised equations for calculating bone-free arm muscle area. Am J Clin Nutr. 1982;36(4):680-90.

Fuller NJ, Laskey MA, Elia M. Assessment of the composition of major body regions by dual-energy X-ray absorptiometry (DEXA), with special reference to limb muscle mass. Clin Physiol. 1992;12(3):253-66.

Brodowicz GR, Mansfield RA, McClung MR, et al. Measurement of body composition in the elderly: dual energy x-ray absorptiometry, underwater weighing, bioelectrical impedance analysis, and anthropometry. Gerontology. 1994;40(6):332-9.

Visser M, van den Heuvel E, Deurenberg P. Prediction equations for the estimation of body composition in the elderly using anthropometric data. Br J Nutr. 1994;71(6):823-33.

Heymsfield SB, Gallagher D, Visser M, et al. Measurement of skeletal muscle: laboratory and epidemiological methods. J Gerontol A Biol Sci Med Sci. 1995;50 Spec No:23-9.

Heymsfield SB, Gallagher D, Grammes J, et al. Upper extremity skeletal muscle mass: potential of measurement with single frequency bioimpedance analysis. Appl Radiat Isot. 1998;49(5-6):473-4.

Guglielmi G, Ponti F, Agostini M, et al. The role of DXA in sarcopenia. Aging Clin Exp Res. 2016;28(6):1047-60.

Janssen I, Heymsfield SB, Wang ZM, et al. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol (1985). 2000;89(1):81-8.

Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 2002;50(5):889-96.

Berkman LF, Seeman TE, Albert M, et al. High, usual and impaired functioning in community-dwelling older men and women: findings from the MacArthur Foundation Research Network on Successful Aging. J Clin Epidemiol. 1993;46(10):1129-40.

Fried LP, Ettinger WH, Lind B, et al. Physical disability in older adults: a physiological approach. Cardiovascular Health Study Research Group. J Clin Epidemiol. 1994;47(7):747-60.

Pahor M, Manini T, Cesari M. Sarcopenia: clinical evaluation, biological markers and other evaluation tools. J Nutr Health Aging. 2009;13(8):724-8.

Newman AB, Kupelian V, Visser M, et al. Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc. 2003;51(11):1602-9.

Bautmans I, Van Puyvelde K, Mets T. Sarcopenia and functional decline: pathophysiology, prevention and therapy. Acta clinica Belgica. 2009;64(4):303-16.

Arango-Lopera VE, Arroyo P, Gutiérrez-Robledo LM, et al. Prevalence of sarcopenia in Mexico City. European geriatric medicine. 2012;3(3):157-60.

Bano G, Trevisan C, Carraro S, et al. Inflammation and sarcopenia: A systematic review and meta-analysis. Maturitas. 2017;96:10-5.

Diz JB, Leopoldino AA, Moreira BS, et al. Prevalence of sarcopenia in older Brazilians: A systematic review and meta-analysis. Geriatr Gerontol Int. 2017;17(1):5-16.

Cruz-Jentoft AJ, Landi F, Schneider SM, et al. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing. 2014;43(6):748-59.

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2018-12-06

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