Inflammatory bowel disease and women’s sexual and reproductive health: a narrative review

Authors

  • Sara M. B. Cunha Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.
  • Maria C. F. Carneiro Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.
  • Cátia D. Rodrigues Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.
  • Cátia L. S. N. S. Rasteiro Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.
  • Teresa P. Teles Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.

DOI:

https://doi.org/10.12957/bjhbs.2020.53531

Abstract

Introduction: Inflammatory bowel disease is a chronic
idiopathic condition involving the gastrointestinal tract.
The disease prevalence is increasing worldwide, affecting
women in childbearing age. Objective: Clinical and practical
review of the women´s sexual and reproductive health in
inflammatory bowel disease with focus in gynaecological
and obstetrical management. Materials and Methods: In this
article we review sexual and reproductive health issues in
women with inflammatory bowel disease in all life stages
and the main particularities of the approach of inflammatory
bowel disease in pregnancy and breastfeeding. Results and
Conclusion: Fertility in women without disease activity is
not decreased comparing to general population, but despite
research is inconsistent there are reports of increased risk of
small for gestational age, preterm delivery, low Apgar score,
congenital anomalies, intrauterine death, miscarriage, venous
thromboembolism and preeclampsia. To improve obstetric
outcomes, a period of 3 to 6 months of disease remission is
recommended before conception. Medication adjustment
may be necessary, and supplementation should be adapted. A
multidisciplinary approach and a comprehensive knowledge
of the disease through all women life stages allows a better
health care.


Keywords: Inflammatory bowel disease, Sexual health,
Reproduction, Pregnancy, Breastfeeding.

Author Biographies

Sara M. B. Cunha, Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.

Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.

Maria C. F. Carneiro, Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.

Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.

Cátia D. Rodrigues, Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.

Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.

Cátia L. S. N. S. Rasteiro, Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal.

Gynaecology and Obstetrics Department, Centro Hospitalar de
Entre o Douro e Vouga, Santa Maria da Feira, Portugal.
Faculdade de Ciências da Saúde, Universidade da Beira Interior,
Covilhã, Portugal.

Teresa P. Teles, Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.

Gynaecology and Obstetrics Department, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal.

References

Huang VW, Chang HJ, Kroeker KI, et al. Management of Inflammatory

Bowel Disease during Pregnancy and Breastfeeding

Varies Widely: A Need for Further Education. Canadian journal

of gastroenterology & hepatology. 2016;2016:6193275.

Kokoszko-Bilska A, Sobkiewicz S, Fichna J. Inflammatory bowel

diseases and reproductive health. Pharmacological reports :

PR. 2016;68(4):859-64.

Nguyen GC, Seow CH, Maxwell C, et al. The Toronto Consensus

Statements for the Management of Inflammatory Bowel

Disease in Pregnancy. Gastroenterology. 2016;150(3):734-57.e1.

Waszczuk E, Waszczuk K, Bohdanowicz-Pawlak A, et al.

Women with inflammatory bowel diseases have a suboptimal

cervical cancer screening rate and are not aware of the

recommended human papilloma virus vaccine. Gynecological

Endocrinology. 2018;34(8):656-8.

Kane S, Khatibi B, Reddy D. Higher incidence of abnormal

Pap smears in women with inflammatory bowel disease. The

American journal of gastroenterology. 2008;103(3):631-6.

Reich JS, Farraye FA, Wasan SK. Preventative Care in the Patient

with Inflammatory Bowel Disease: What Is New? Digestive

diseases and sciences. 2016;61(8):2205-16.

van der Woude CJ, Ardizzone S, Bengtson MB, et al. The

second European evidenced-based consensus on reproduction

and pregnancy in inflammatory bowel disease. J Crohns

Colitis. 2015;9(2):107-24.

Contraceptive choices for women with inflammatory bowel

disease. The journal of family planning and reproductive health

care. 2003;29(3):127-35.

Bonthala N, Kane S. Updates on Women’s Health Issues in

Patients with Inflammatory Bowel Disease. Curr Treat Options

Gastroenterol. 2018;16(1):86-100.

Freour T, Miossec C, Bach-Ngohou K, Dejoie T, et al. Ovarian

reserve in young women of reproductive age with Crohn’s

disease. Inflammatory bowel diseases. 2012;18(8):1515-22.

Brah TK, Abel DE. Inflammatory Bowel Disease and Pregnancy.

Topics in Obstetrics & Gynecology. 2017;37(17):1-7.

Hashash JG, Kane S. Pregnancy and Inflammatory Bowel

Disease. Gastroenterology & hepatology. 2015;11(2):96-102.

Monsen U, Broström O, Nordenvall B, et al. Prevalence of

inflammatory bowel disease among relatives of patients with

ulcerative colitis. Scandinavian journal of gastroenterology.

;22(2):214-8.

Fielding JF. The relative risk of inflammatory bowel disease

among parents and siblings of Crohn’s disease patients. Journal

of clinical gastroenterology. 1986;8(6):655-7.

Direção Geral da Saúde. Vigilância de Gravidez de Baixo Risco.

Lisboa, 2015

Julsgaard M. Adherence to medical treatment in relation to

pregnancy, birth outcome & breastfeeding behavior among

women with Crohn’s disease. Danish medical journal. 2016;63(7).

Abdul Sultan A, West J, Ban L, et al. Adverse Pregnancy Outcomes Among Women with Inflammatory Bowel Disease:

A Population-Based Study from England. Inflammatory bowel

diseases. 2016;22(7):1621-30.

Pedersen N, Bortoli A, Duricova D, et al. The course of

inflammatory bowel disease during pregnancy and postpartum:

a prospective European ECCO‐EpiCom Study of 209

pregnant women. Alimentary pharmacology & therapeutics.

;38(5):501-12.

Boyd HA, Basit S, Harpsøe MC, et al. Inflammatory bowel

disease and risk of adverse pregnancy outcomes. PLoS One.

;10(6):e0129567.

Djokanovic N, Klieger-Grossmann C, Pupco A, et al. Safety

of infliximab use during pregnancy. Reproductive toxicology.

;32(1):93-7.

Julsgaard M, Hvas CL, Gearry RB, et al. Fecal Calprotectin

Is Not Affected by Pregnancy: Clinical Implications for the

Management of Pregnant Patients with Inflammatory Bowel

Disease. Inflammatory bowel diseases. 2017;23(7):1240-6.

Shitrit AB-G, Grisaru-Granovsky S, Ya’acov AB, et al. Management

of inflammatory bowel disease during pregnancy.

Digestive diseases and sciences. 2016;61(8):2194-204.

Direção geral de saúde: Aporte de iodo em mulheres na preconceção,

gravidez e amamentação. Lisboa, 2013, pp 1-6.

Yakut M, Üstün Y, Kabaçam G, et al. Serum vitamin B12 and

folate status in patients with inflammatory bowel diseases.

European journal of internal medicine. 2010;21(4):320-3.

Gasche C, Berstad A, Befrits R, et al. Guidelines on the

diagnosis and management of iron deficiency and anemia in

inflammatory bowel diseases#. Inflammatory bowel diseases.

;13(12):1545-53.

Poturoglu S, Ormeci AC, Duman AE. Treatment of pregnant

women with a diagnosis of inflammatory bowel disease. World

journal of gastrointestinal pharmacology and therapeutics.

;7(4):490.

Gaidos JKJ, Kane SV. Sexuality, Fertility, and Pregnancy in

Crohn’s Disease. Gastroenterology clinics of North America.

;46(3):531-46.

William J. Sandbor. A SPECIAL MEETING REVIEW EDITION:

Highlights in Crohn’s Disease and Ulcerative Colitis: May 19-

, 2012. San Diego

Gaidos JK, Kane SV. Managing IBD Therapies in Pregnancy.

Current treatment options in gastroenterology. 2017;15(1):71-83.

Bortoli A, Pedersen N, Duricova D, et al. Pregnancy outcome in

inflammatory bowel disease: prospective European case‐control

ECCO‐EpiCom study, 2003–2006. Alimentary pharmacology

& therapeutics. 2011;34(7):724-34.

Østensen M, Khamashta M, Lockshin M, et al. Anti-inflammatory

and immunosuppressive drugs and reproduction. Arthritis

research & therapy. 2006;8(3):209.

Angelberger S, Reinisch W, Messerschmidt A, et al. Long-term

follow-up of babies exposed to azathioprine in utero and via

breastfeeding. Journal of Crohn’s and Colitis. 2011;5(2):95-100.

Katz JA, Antoni C, Keenan GF, et al. Outcome of pregnancy in

women receiving infliximab for the treatment of Crohn’s disease

and rheumatoid arthritis. The American journal of gastroenterology.

;99(12):2385.

McConnell RA, Mahadevan U. Pregnancy and the patient with

inflammatory bowel disease: fertility, treatment, delivery, and

complications. Gastroenterology Clinics. 2016;45(2):285-301.

Moens A, van Hoeve K, Humblet E, et al. Outcome of Pregnancies

in Female Patients With Inflammatory Bowel Diseases

Treated With Vedolizumab. Journal of Crohn’s and Colitis.

;13(1):12-8.

Lee KE, Jung S-A, Park SH, et al. Influence of anti-tumor

necrosis factor-alpha therapy to pregnant inflammatory bowel

disease women and their children’s immunity. Intestinal research.

;17(2):237.

Chaparro M, Verreth A, Lobaton T, et al. Long-term safety

of in utero exposure to anti-TNFα drugs for the treatment of

inflammatory bowel disease: Results from the multicenter european

TEDDY study. The American journal of gastroenterology.

;113(3):396.

The Transfer of Drugs and Other Chemicals Into Human Milk.

Pediatrics. 2001;108(3):776-89.

Bar-Oz B, Moretti ME, Boskovic R, O’Brien L, Koren G. The

safety of quinolones--a meta-analysis of pregnancy outcomes.

European journal of obstetrics, gynecology, and reproductive

biology. 2009;143(2):75-8.

McConnell RA, Mahadevan U. Use of immunomodulators and

biologics before, during, and after pregnancy. Inflammatory

bowel diseases. 2015;22(1):213-23

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Published

2020-06-05

How to Cite

Cunha, S. M. B., Carneiro, M. C. F., Rodrigues, C. D., Rasteiro, C. L. S. N. S., & Teles, T. P. (2020). Inflammatory bowel disease and women’s sexual and reproductive health: a narrative review. Brazilian Journal of Health and Biomedical Sciences, 19(1), 48–56. https://doi.org/10.12957/bjhbs.2020.53531

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Original Papers