Efeito da suplementação de probióticos no diabetes mellitus: uma revisão sistemática
DOI:
https://doi.org/10.12957/rhupe.2016.28238Resumo
Devido à importância de se tratar o diabetes mellitus e prevenir suas complicações, o objetivo dessa revisão sistemática foi verificar os efeitos da suplementação de probióticos no tratamento do paciente diabético e sua contribuição na prevenção de suas complicações. Foram utilizadas as plataformas de pesquisa PubMed, Science Direct, Lilacs e Medline. Foram encontrados 11 ensaios clínicos. As principais cepas utilizadas foram dos gêneros Lactobacillus e Bifidobacterium. Os principais efeitos da suplementação de probióticos foram redução estatisticamente significativa da glicemia de jejum, da hemoglobina glicada, da frutosamina e da resistência à insulina, dos níveis séricos de colesterol total e de LDL-C, enquanto o de HDL-C aumentou. A suplementação de probióticos parece melhorar o controle glicêmico e metabólico de pacientes diabéticos.
Descritores: Probióticos; Diabetes Mellitus; Lactobacillus; Suplementação Alimentar; Complicações do Diabetes.
Referências
Sociedade Brasileira de Diabetes (SBD). Diretrizes da Sociedade Brasileira de Diabetes: 2014/2015. São Paulo: AC Farmacêutica; 2015.
Tao Z, Shi A, Zhao J. Epidemiological perspectives of diabetes. Cell BiochemBiophys 2015; 73(1):1-5
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Sistema de Informações sobre Mortalidade. Disponível em: http://tabnet.datasus.gov.br/cgi/ deftohtm.exe?idb2012/c12.def. Acessado em 20/02/2016.
Mirmiran P, Bahadoran Z, Azizi F. Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review. World J Diabetes 2014;5(3):267-81.
Zhang Y, Zhang H. Microbiota associated with type 2 diabetes and its related complications. Food Sci Hum Wellness. 2013;2(3):167-72.
Esteve E, Ricart W, Fernandez-Real J. Gut microbiota interactions with obesity, insulin resistance and type 2 diabetes: did gut microbiote co-evolve with insulin resistance?.Curr Opin Clin Nutr Metab Care. 2011;14(5):483-90.
Salminen S, Ouwehand A, Benno Y, et al. Probiotics: how should they be defined?.Trends Food Sci Technol. 1999;10(3):107-10.
Tonucci LB, Santos KO, Ferreira CLLF, et al. Clinical Application of Probiotics in Diabetes Mellitus: Therapeutics and New Perspectives.Crit Rev Food SciNutr. 2015.
Mazloom Z, Yousefinejad A, Dabbaghmanesh MH. Effect of probiotics on lipid profile, glycemic control, insulin action, oxidative stress, and inflammatory markers in patients with type 2 diabetes: a clinical trial. Iran J Med Sci 2013;38(1):38-43.
Razmpoosh E, Javadi M, Ejtahed HS, et al. Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review. Diabetes Metab Res Rev 2015;32:143-68.
Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, et al. Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition. 2012;28(5): 539-43.
Hove KD, Brøns C, Færch K, et al. Effects of 12 weeks of treatment with fermented milk on blood pressure, glucose metabolism and markers of cardiovascular risk in patients with type 2 diabetes: a randomised double-blind placebo-controlled study. Eur J Endocrinol. 2015;172(1):11-20.
Ostadrahimi A, Taghizadeh A, Mobasseri M, et al. Effect of probiotic fermented milk (kefir) on glycemic control and lipid profile in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Iran J Public Health. 2015; 44(2): 228-37.
Mohamadshahi M, Veissi M, Haidari F, et al. Effects of probiotic yogurt consumption on lipid profile in type 2 diabetic patients: A randomized controlled clinical trial. J Res Med Sci. 2014;19(6):531-6.
Tonucci LB, Santos KMO, Oliveira LL, et al. Clinical application of probiotics in type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled study. ClinNutr. 2015;1-8.
Andreasen AS, Larsen N, Pedersen-Skovsgaard T, et al. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr. 2010;104(12):1831-8.
Dolatkhah N, Hajifaraji M, Abbasalizadeh F, et al. Is there a value for probiotic supplements in gestational diabetes mellitus? A randomized clinical trial. J Health Popul Nutr. 2015;33(1):1-12.
Lindsay KL, Brennan L, Kennelly MA, et al. Impact of probiotics in women with gestational diabetes mellitus on metabolic health: a randomized controlled trial. Am J Obstet Gynecol. 2015;212(4):496-e1.
Zhang Q, Wu Y, Fei X. Effect of probiotics on glucose metabolism in patients with type 2 diabetes: A meta-analysis of randomized controlled trials. Medicina (Kaunas). 2015.
Yun SI, Park HO, Kang JH. Effect of Lactobacillus gasseri BNR17 on blood glucose levels and body weight in a mouse model of type 2 diabetes. J ApplMicrobiol. 2009;107(5):1681-6.
Chen P, Zhang Q, Dang H, et al. Oral administration of Lactobacillus rhamnosus CCFM0528 improves glucose tolerance and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice. J Funct Foods. 2014;10:318-26.
Chen P, Zhang Q, Dang H, et al. Antidiabetic effect of Lactobacillus casei CCFM0412 on mice with type 2 diabetes induced by a high-fat diet and streptozotocin. Nutrition. 2014;30(9):1061-8.
Marazza JA, LeBlanc JG, Giori GS, et al. Soymilk fermented with Lactobacillus rhamnosus CRL981 ameliorates hyperglycemia, lipid profiles and increases antioxidant enzyme activities in diabetic mice. J Funct Foods. 2013;5(4):1848-53.
Yadav H, Jain S, Sinha PR. The effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei on gastropathic consequences in diabetic rats. J Med Food. 2008;11(1):62-68.
Manaer T, Yu L, Zhang Y, et al. Anti-diabetic effects of shubat in type 2 diabetic rats induced by combination of high-glucose-fat diet and low-dose streptozotocin. J Ethnopharmacol. 2015;169:269-74.
Kasinska MA, Drzewoski J. Effectiveness of probiotics in type 2 diabetes: a meta-analysis. Pol Arch Med Wewn. 2015;125:803-13.
Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, et al. Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus. J Dairy Sci. 2011; 94(7):3288-94.
Bernini LJ, Simão ANC, Alfieri DF, et al. Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: a randomized trial. Nutrition. 2015.
Bejar W, Hamden K, Salah RB, et al. Lactobacillus plantarum TN627 significantly reduces complications of alloxan-induced diabetes in rats. Anaerobe. 2013;24:4-11.
Babashahi M, Mirlohi M, Ghiasvand R, et al. Comparison of soymilk and probiotic soymilk effects on serum high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in diabetic Wistar rats. ARYA atheroscler. 2015;11(Suppl 1):88.
Hariri M, Salehi R, Feizi A, et al. The effect of probiotic soy milk and soy milk on anthropometric measures and blood pressure in patients with type II diabetes mellitus: A randomized double-blind clinical trial. ARYA Atheroscler. 2015;11(Suppl 1):74-80.
Lye HS, Kuan CY, Ewe JA, et al. The improvement of hypertension by probiotics: effects on cholesterol, diabetes, renin, and phytoestrogens. Int J Mol Sci. 2009;10(9):3755-75.
Zarfeshani A, Khaza’ai H, Ali RM, et al. Effect of Lactobacillus casei on the production of pro-inflammatory markers in streptozotocin-induced diabetic rats. Probiotics Antimicrob Proteins. 2011;3(3-4):168-74.
Davari S, Talaei SA, Alaei H. Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: behavioral and electrophysiological proofs for microbiome–gut–brain axis. Neuroscience. 2013;240:287-96.
Everard A, Matamoros S, Geurts L, et al. Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db/db mice. M Bio. 2014;5(3): e01011-14.
Sato J, Kanazawa A, Ikeda F, et al. Gut dysbiosis and detection of “live gut bacteria” in blood of Japanese patients with type 2 diabetes. Diabetes Care. 2014;37(8):2343-50.
Li C, Ding Q, Nie SP, et al. Carrot juice fermented with Lactobacillus plantarum NCU116 ameliorates Type 2 diabetes in rats. J Agric Food Chem. 2014;62(49):11884-91.
